This column focuses on advances in brain science and their implications for mental health, psychological well-being, and health-related behavior. It welcomes research on neural mechanisms, neuropsychological processes, neuromodulation, brain-based interventions, digital and adaptive technologies, and lifespan mental health. The column particularly encourages interdisciplinary studies that connect neuroscience with psychology, psychiatry, behavioral medicine, and patient-centered care. By integrating biological, psychological, and clinical perspectives, this column aims to promote a broader understanding of how brain science can inform prevention, assessment, intervention, and long-term support for mental health across diverse populations and life stages.