Risk Factors of Mental Health Disorders among Immigrant and Non-Immigrant Adolescent Visiting Healthcare Centers: A Population-based Cross-Sectional Study

Background
Adolescence is a high-risk period for mental disorders, but prevalence and risk factors among Iranian and immigrant youth remain unclear.
Objective
This study aims to compare mental disorder prevalence and associated factors between Iranian and immigrant adolescents in Mashhad, Iran, to inform services.
Methods
This population-based cross-sectional study was conducted from March 2021 to December 2023 among adolescents aged 5–18 years visiting healthcare centers in Mashhad, Iran. The study population included all Iranian and immigrant adolescents who completed mental health evaluations documented in the Sina Electronic Health Record system (SinaEHR®). Logistic regression analysis was performed to identify factors associated with mental disorders, adjusting for sociodemographic variables. Candidate predictor variables with p<0.25 in bivariate analyses were included in the final multivariate model.
Results
Of 1,034,962 adolescents, 499,165 (48.2%) were female and 535,797 (51.8%) were male. The prevalence of mental disorders was 12.6% among Iranian adolescents and 14.4% among immigrants. Common conditions were anxiety, depression, hyperactivity, epilepsy, intellectual disability, and multi-symptom disorders. Significant risk factors included older age, female, underweight status, comorbidities, welfare service use, not living with both parents, abuse, family adversity, and secondhand smoke exposure (all p<0.05). Fruit consumption, physical activity, frequent meals, less gaming, and insurance coverage were protective (all p<0.05). For immigrants, residence cards offered additional protection (p=0.02). No significant differences in overall mental health status between groups.
Conclusion
Mental disorders affected a notable portion of both Iranian and immigrant adolescents, with key risk and protective factors identified. Despite slight variations, overall mental health status was comparable across groups, reflecting global patterns.
- Kaufman JA, Salas-Hernández LK, Komro KA, Livingston MD. Effects of increased minimum wages by unemployment rate on suicide in the USA. J Epidemiol Community Health. 2020;74(3):219-24. doi: 10.1136/jech-2019-212981
- Bennett S, Walkup JT. Anxiety Disorders in Children and Adolescents: Epidemiology, Pathogenesis, Clinical Manifestations, and Course. United States: Up to Date; 2019.
- Maghsoudi J, Yazdani M, Mehrabi T. The effect of acquiring life skills through humor on social adjustment rate of the female students. Iran J Nurs Midwifery Res. 2010;15(4):195-201.
- Talepasand S, Mohammadi MR, Alavi SS, et al. Psychiatric disorders in children and adolescents: Prevalence and sociodemographic correlates in Semnan Province in Iran. Asian J Psychiatry. 2019;40:9-14. doi: 10.1016/j.ajp.2019.01.007
- Jesuthasan J, Sönmez E, Abels I, et al. Near-death experiences, attacks by family members, and absence of health care in their home countries affect the quality of life of refugee women in Germany: A multi-region, cross-sectional, gender-sensitive study. BMC Med. 2018;16:15. doi: 10.1186/s12916-017-1003-5
- Zbidat A, Georgiadou E, Borho A, Erim Y, Morawa E. The perceptions of trauma, complaints, somatization, and coping strategies among Syrian refugees in Germany-a qualitative study of an at-risk population. Int J Environ Res Public Health. 2020;17(3):693. doi: 10.3390/ ijerph17030693
- Peyre H, Hoertel N, Stordeur C, et al. Contributing factors and mental health outcomes of first suicide attempt during childhood and adolescence: Results from a nationally representative study. J Clin Psychiatry. 2017;78(6):e622-e630. doi: 10.4088/JCP.16m10876
- Rosenthal T. Immigration and acculturation: Impact on health and well-being of immigrants. Curr Hypertens Rep. 2018;20(8):70. doi: 10.1007/ s11906-018-0872-0
- Blackmore R, Gray KM, Boyle JA, et al. Systematic review and meta-analysis: The prevalence of mental illness in child and adolescent refugees and asylum seekers. J Am Acad Child Adolesc Psychiatry. 2020;59(6):705-714. doi: 10.1016/j. jaac.2019.11.011
- Riahi A, Hariri N, Nooshinfard F. Study of health Information needs and barriers to access among afghan and iraqi immigrants in Iran. J North Khorasan Univ Med Sci. 2016;7(3):597-610.
- Remoue Gonzales S, Higgs J. Perspectives on Integrated Behavioral Health in pediatric care with immigrant children and adolescents in a Federally Qualified Health Center in Texas. Clin Child Psychol Psychiatry. 2020;25(3):625-635. doi: 10.1177/1359104520914724
- Norouzi M, Amiri Z, Farkhani EM, Hoseini SJ, Khosravi Asl T. Advancing healthcare infrastructure: The features of Iran’s sina electronic health record system. Epidemiol Health System J. 2024;11(2):48-54.
- Cotton SM, Menssink J, Filia K, et al. The psychometric characteristics of the Kessler Psychological Distress Scale (K6) in help-seeking youth: What do you miss when using it as an outcome measure? Psychiatry Res. 2021;305:114182. doi: 10.1016/j. psychres.2021.114182
- O’Hare K, Watkeys O, Dean K, et al. Childhood schizotypy and adolescent mental disorder. Schizophr Bull. 2024;50(1):69-77. doi: 10.1093/ schbul/sbad132
- Georgiades K, Boyle MH, Duku E. Contextual influences on children’s mental health and school performance: The moderating effects of family immigrant status. Child Dev. 2007;78(5):1572-1591. doi: 10.1111/j.1467-8624.2007.01084.x
- Back Nielsen M, Carlsson J, Køster Rimvall M, Petersen JH, Norredam M. Risk of childhood psychiatric disorders in children of refugee parents with post-traumatic stress disorder: A nationwide, register-based, cohort study. Lancet Public Health. 2019;4(7):e353-e359. doi: 10.1016/ S2468-2667(19)30077-5
- Amiri S, Mohammadi MR, Ahmadi N, et al. Prevalence of psychiatric disorders among children and adolescents in the East Azerbaijan Province, Tabriz, Iran in 2017. Iran J Psychiatry Behav Sci. 2019;13(4):e88594. doi: 10.5812/ijpbs.88594
- Mojahed A, Rigi Kooteh B, Mohammadi MR, et al. Prevalence of mental disorders among children and teenagers in Sistan and Baluchestan Province, Iran. Casp J Health Res. 2021;6(3):91-100. doi: 10.32598/CJHR.6.3.5
- Mohammadi MR, Ahmadi N, Khaleghi A, et al. Prevalence and correlates of psychiatric disorders in a national survey of Iranian children and adolescents. Iran J Psychiatry. 2019;14(1):1-15. doi: 10.18502/ijps.v14i1.418
- Hafekost J, Lawrence D, Boterhoven de Haan K, et al. Methodology of young minds matter: The second Australian child and adolescent survey of mental health and wellbeing. Aust N Z J Psychiatry. 2016;50(9):866-875. doi: 10.1177/0004867415622270
- Inkelis SM, Ancoli-Israel S, Thomas JD, Bhattacharjee R. Elevated risk of depression among adolescents presenting with sleep disorders. J Clin Sleep Med. 2021;17(4):675-683. doi: 10.5664/ jcsm.8996
- Yu Y, Mo PKH, Zhang J, Li J, Lau JTF. Maladaptive cognitions, loneliness, and social anxiety as potential moderators of the association between Internet gaming time and Internet gaming disorder among adolescent Internet gamers in China. Addict Behav. 2022;129:107239. doi: 10.1016/j. addbeh.2022.107239
- David OA, Predatu R, Cardoș RAI. Effectiveness of the REThink therapeutic online video game in promoting mental health in children and adolescents. Internet Interv. 2021;25:100391. doi: 10.1016/j.invent.2021.100391
- Mazza C, Ricci E, Marchetti D, et al. How personality relates to distress in parents during the COVID-19 lockdown: The mediating role of child’s emotional and behavioral difficulties and the moderating effect of living with other people. Int J Environ Res Public Health. 2020;17(17):6236. doi: 10.3390/ijerph17176236
- Wicks S, Hjern A, Gunnell D, Lewis G, Dalman C. Social adversity in childhood and the risk of developing psychosis: A national cohort study. Am J Psychiatry. 2005;162(9):1652-1657. doi: 10.1176/ appi.ajp.162.9.1652
- Mutumba M, Bauermeister JA, Harper GW, et al. Psychological distress among Ugandan adolescents living with HIV: Examining stressors and the buffering role of general and religious coping strategies. Global Public Health. 2017;12(12):1479-1491. doi: 10.1080/17441692.2016.1170871
- Melkam M, Nenko G, Demilew D. Common mental disorders and associated factors among high school students in Debre Markos Town, Northwest Ethiopia: An institutional-based cross-sectional study. BMJ Open. 2022;12(11):e059894. doi: 10.1136/bmjopen-2021-059894
- Bronsard G, Alessandrini M, Fond G, et al. The prevalence of mental disorders among children and adolescents in the child welfare system: A systematic review and meta-analysis. Medicine (Baltimore). 2016;95(7):e2622. doi: 10.1097/ MD.0000000000002622
- Mohammadi MR, Mostafavi SA, Hooshyari Z, Khaleghi A, Ahmadi N. Body mass index status across different psychiatric disorders in a national survey amongst children and adolescents: To identify the role of gender. Iran J Psychiatry. 2019;14(4):253-264. doi: 10.18502/ijps.v14i4.1975
- Gaskin JL, Pulver AJ, Branch K, Kabore A, James T, Zhang J. Perception or reality of body weight: Which matters to the depressive symptoms. J Affect Disord. 2013;150(2):350-355. doi: 10.1016/j. jad.2013.04.017
- Guan Q, Huan F, Wang Y, et al. The relationship between secondhand smoking exposure and mental health among never-smoking adolescents in school: Data from the Global School-based Student Health Survey. J Affect Disord. 2022;311:486-493. doi: 10.1016/j.jad.2022.05.121
- Bandiera FC, Richardson AK, Lee DJ, He JP, Merikangas KR. Secondhand smoke exposure and mental health among children and adolescents. Arch Pediatr Adolesc Med. 2011;165(4):332-338. doi: 10.1001/archpediatrics.2011.30
- Rizk Y, Hoteit R, Khater B, Naous J. Psychosocial wellbeing and risky health behaviors among Syrian adolescent refugees in South Beirut: A study using the HEEADSSS interviewing framework. Front Psychol. 2023;14:1019269. doi: 10.3389/fpsyg.2023.1019269
- Afifi TO, MacMillan HL, Boyle M, Taillieu T, Cheung K, Sareen J. Child abuse and mental disorders in Canada. CMAJ. 2014;186(9):E324-E332. doi: 10.1503/cmaj.131792
- Blazquez A, Castro-Fornieles J, Baeza I, Morer A, Martinez E, Lazaro L. Differences in psychopathology between immigrant and native adolescents admitted to a psychiatric inpatient unit. J Immigr Minor Health. 2015;17(6):1715-1722. doi: 10.1007/s10903-014-0143-3
- Zlotnick C, Birenbaum-Carmeli D, Goldblatt H, Dishon Y, Taychaw O, Shadmi E. Adolescent immigrants, the impact of gender on health status. Eur J Public Health. 2017;27(3):453-459. doi: 10.1093/ eurpub/ckw208
- Kwak K, Rudmin F. Adolescent health and adaptation in Canada: Examination of gender and age aspects of the healthy immigrant effect. Int J Equity Health. 2014;13:103. doi: 10.1186/s12939-014-0103-5
- Kwak K. An evaluation of the healthy immigrant effect with adolescents in Canada: Examinations of gender and length of residence. Soc Sci Med. 2016;157:87-95. doi: 10.1016/j. socscimed.2016.03.017
- Liu Y, Maltais NS, Milner-Bolotin M, Chachashvili-Bolotin S. Investigating adolescent psychological wellbeing in an educational context using PISA 2018 Canadian data. Front Psychol. 2024;15:1416631. doi: 10.3389/fpsyg.2024.1416631
- Rose T, Lambert S, Liu C, et al. Socio-ecological domains and adolescent mental health: An application of the dual-factor model. J Res Adolesc. 2025;35(2):e70029. doi: 10.1111/jora.70029
- Paul RA. Identity and community: Erikson reconsidered. Psychoanal Q. 2023;92(3):377-405. doi: 10.1080/00332828.2023.2267527