Psychological and neuropsychological clinical impact in brain cancer patients and evidence-based psychological intervention: a systematic review of the literature

Background
Cancer patients may suffer from psychological disorders related to their health condition. Various medical, surgical, and interventional procedures, alongside the distinct tumor localization, have been linked to an elevated predisposition towards psychological disorders, including but not limited to depression, anxiety, post-traumatic stress disorder (PTSD), and cognitive impairments.
Objective
To systematically review the literature on neurocognitive rehabilitation of patients before and after brain cancer.
Methods
The systematic review was performed according to the PRISMA 2020 guidelines for the systematic review of the PRISMA Group. The literature search was conducted from February 2022 to December 2022 in the databases of PubMed, APA PsycNet, and Web of Science. The focus was on cognitive-behavioural treatments, with Goal Management Training (GMT), and also an app on the iPad- ReMind- that includes psychoeducation, strategy training, and retraining, and new technologies such as virtual reality, in patients with cognitive deficits after neurosurgery.
Conclusions
Overall, neurocognitive rehabilitation had an improvement on cancer patients and a recovery of executive and cognitive functions, a better quality of life, and psychological well-being.
1. Fondazione AIRC per la Ricerca sul Cancro. Accessed June 9, 2023. https://www.airc.it/cancro/informazioni-tumori/guida-ai%20tumori/tumore-al-cervello
2. Grassi L. Psychiatric and psychosocial implications in cancer care: the agenda of psycho-oncology. Epidemiol Psychiatr Sci. 2020;29:e89. doi:10.1017/s2045796019000829
3. Raffa G, Quattropani MC, Germanò A. When imaging meets neurophysiology: the value of navigated transcranial magnetic stimulation for preoperative neurophysiological mapping prior to brain tumor surgery. Neurosurg Focus. 2019;47(6):E10. doi:10.3171/2019.9.focus19640
4. Mussa R, Torta A. Psiconcologia, Il Legame Tra Psiche e Soma. Ediermes
5. Anuk D, Özkan M, Kizir A, Özkan S. The characteristics and risk factors for common psychiatric disorders in patients with cancer seeking help for mental health. BMC Psychiatry. 2019;19(1):269. doi:10.1186/s12888-019-2251-z
6. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. American Psychiatric Association; 2013. doi:10.1176/appi.books.9780890425596
7. LINEE GUIDA SIPO.pdf. Accessed June 9, 2023. https://www.siponazionale.it/pdf_2008/LINEE%20GUIDA%20SIPO.pdf
8. Ownsworth T, Hawkes A, Steginga S, Walker D, Shum D. A biopsychosocial perspective on adjustment and quality of life following brain tumor: A systematic evaluation of the literature. Disability and Rehabilitation. 2009;31(13):1038-1055. doi:10.1080/09638280802509538
9. Day J, Gillespie DC, Rooney AG, et al. Neurocognitive Deficits and Neurocognitive Rehabilitation in Adult Brain Tumors. Curr Treat Options Neurol. 2016;18(5):22. doi:10.1007/s11940-016-0406-5
10. Anderson SW, Damasio H, Tranel D. Neuropsychological Impairments Associated With Lesions Caused by Tumor or Stroke. Archives of Neurology. 1990;47(4):397-405. doi:10.1001/archneur.1990.00530040039017
11. Faulkner JW, Wilshire CE, Parker AJ, Cunningham K. An evaluation of language in brain tumor patients using a new cognitively motivated testing protocol. Neuropsychology. 2017;31(6):648-665. doi:10.1037/neu0000374
12. Zucchella C, Pace A, Pierelli F, Bartolo M. Cognitive rehabilitation in neuro-oncological patients: three case reports. CMI. 2012;6(2):67-73. doi:10.7175/cmi.v6i2.625
13. Raffa G, Scibilia A, Conti A, et al. Multimodal Surgical Treatment of High-Grade Gliomas in the Motor Area: The Impact of the Combination of Navigated Transcranial Magnetic Stimulation and Fluorescein-Guided Resection. World Neurosurg. 2019;128:e378-e390. doi:10.1016/j.wneu.2019.04.158
14. Raffa G, Quattropani MC, Scibilia A, et al. Surgery of language-eloquent tumors in patients not eligible for awake surgery: the impact of a protocol based on navigated transcranial magnetic stimulation on presurgical planning and language outcome, with evidence of tumor-induced intra-hemispheric plasticity. Clin Neurol Neurosurg. 2018;168:127-139. doi:10.1016/j.clineuro.2018.03.009
15. Coomans MB, Van Der Linden SD, Gehring K, Taphoorn MJB. Treatment of cognitive deficits in brain tumour patients: current status and future directions. Current Opinion in Oncology. 2019;31(6):540-547. doi:10.1097/cco.0000000000000581
16. What is Cognitive Behavioral Therapy? https://www.apa.org. Accessed June 9, 2023. https://www.apa.org/ptsd-guideline/patients-and-families/cognitive-behavioral
17. Daniels S. Cognitive Behavior Therapy for Patients With Cancer. J Adv Pract Oncol. 2015;6(1):54-56.
18. Compen F, Bisseling E, Schellekens M, et al. Face-to-Face and Internet-Based Mindfulness-Based Cognitive Therapy Compared With Treatment as Usual in Reducing Psychological Distress in Patients With Cancer: A Multicenter Randomized Controlled Trial. JCO. 2018;36(23):2413-2421. doi:10.1200/jco.2017.76.5669
19. Lagravinese G, Sardone R, De Trane S, et al. Intensive Neurofeedback-based Training to Improve Impaired Attention and Executive Functions Secondary to Resection of Tuberculum Sellae Meningioma: A Case Study. NR. 2021;8(3):149-161. doi:10.15540/nr.8.3.149
20. Caponnetto P, Triscari S, Maglia M, Quattropani MC. The Simulation Game—Virtual Reality Therapy for the Treatment of Social Anxiety Disorder: A Systematic Review. IJERPH. 2021;18(24):13209. doi:10.3390/ijerph182413209
21. Page MJ, Moher D, Bossuyt PM, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. Published online March 29, 2021:n160. doi:10.1136/bmj.n160
22. Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. Published online August 28, 2019:l4898. doi:10.1136/bmj.l4898
23. Richard NM, Bernstein LJ, Mason WP, et al. Cognitive rehabilitation for executive dysfunction in brain tumor patients: a pilot randomized controlled trial. J Neurooncol. 2019;142(3):565-575. doi:10.1007/s11060-019-03130-1
24. Van Der Linden SD, Sitskoorn MM, Rutten GJM, Gehring K. Feasibility of the evidence-based cognitive telerehabilitation program Remind for patients with primary brain tumors. J Neurooncol. 2018;137(3):523-532. doi:10.1007/s11060-017-2738-8
25. van der Linden SD, Rutten GJM, Dirven L, et al. eHealth cognitive rehabilitation for brain tumor patients: results of a randomized controlled trial. J Neurooncol. 2021;154(3):315-326. doi:10.1007/s11060-021-03828-1
26. Yoon J, Chun MH, Lee SJ, Kim BR. Effect of Virtual Reality–Based Rehabilitation on Upper-Extremity Function in Patients with Brain Tumor: Controlled Trial. American Journal of Physical Medicine & Rehabilitation. 2015;94(6):449-459. doi:10.1097/phm.0000000000000192
27. Yang S, Chun MH, Son YR. Effect of Virtual Reality on Cognitive Dysfunction in Patients With Brain Tumor. Ann Rehabil Med. 2014;38(6):726. doi:10.5535/arm.2014.38.6.726
28. Taylor J, Weyer-Jamora C, Brie M, et al. NCOG-21. INTERIM RESULTS OF THREE COGNITIVE REHABILITATION STRATEGIES IN PATIENTS WITH LOWER GRADE GLIOMAS. NeuroOncol. 2020;22(Suppl 2):ii133-ii134. doi:10.1093/neuonc/noaa215.560
29. Krasny-Pacini A, Chevignard M, Evans J. Goal Management Training for rehabilitation of executive functions: a systematic review of effectivness in patients with acquired brain injury. Disability and Rehabilitation. 2014;36(2):105-116. doi:10.3109/09638288.2013.777807
30. Egset KS, Weider S, Stubberud J, et al. Cognitive Rehabilitation for Neurocognitive Late Effects in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Feasibility and Case-Series Study. Front Psychol. 2021;12:724960. doi:10.3389/fpsyg.2021.724960
31. van Lonkhuizen PJC, Klaver KM, Wefel JS, Sitskoorn MM, Schagen SB, Gehring K. Interventions for cognitive problems in adults with brain cancer: A narrative review. Eur J Cancer Care (Engl). 2019;28(3):e13088. doi:10.1111/ecc.13088